Quantal noise from human red cone pigment
نویسندگان
چکیده
منابع مشابه
Human cone pigment expressed in transgenic mice yields altered vision.
Genetically driven alterations in the complement of retinal photopigments are fundamental steps in the evolution of vision. We sought to determine how a newly added photopigment might impact vision by studying a transgenic mouse that expresses a human cone photopigment. Electroretinogram (ERG) measurements indicate that the added pigment works well, significantly changing spectral sensitivity w...
متن کاملMutually exclusive expression of human red and green visual pigment-reporter transgenes occurs at high frequency in murine cone photoreceptors.
This study examines the mechanism of mutually exclusive expression of the human X-linked red and green visual pigment genes in their respective cone photoreceptors by asking whether this expression pattern can be produced in a mammal that normally carries only a single X-linked visual pigment gene. To address this question, we generated transgenic mice that carry a single copy of a minimal huma...
متن کاملRole of a locus control region in the mutually exclusive expression of human red and green cone pigment genes.
Trichromacy in humans and other Old World primates evolved from a dichromatic color vision system approximately 30-40 million years ago. One essential part of this evolution was the duplication and divergence of sequences on the X chromosome to create the present-day red and green cone pigment genes. Earlier work demonstrated that a locus control region (LCR) located upstream of these genes is ...
متن کاملRod - and Cone - driven Responses in Mice Expressing Human L - Cone 1 Pigment 2 3 4
3 4 Tina I Tsai , Jenny Atorf 1, , Maureen Neitz, Jay Neitz, Jan Kremers 5 6 1 Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany 7 2 Department of Biology, Animal Physiology, FAU Erlangen-Nürnberg, Erlangen, Germany 8 3 Vision Sciences, University of Washington, Seattle, Washington, USA 9 4 Department of Anatomy II, University of Erlangen-Nürnberg, Germany 10 5 School...
متن کاملRod- and cone-driven responses in mice expressing human L-cone pigment.
The mouse is commonly used for studying retinal processing, primarily because it is amenable to genetic manipulation. To accurately study photoreceptor driven signals in the healthy and diseased retina, it is of great importance to isolate the responses of single photoreceptor types. This is not easily achieved in mice because of the strong overlap of rod and M-cone absorption spectra (i.e., ma...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2008
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2110